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Search for "MURALI T.S.": 2 articles found.
PANCHAL S., MURALI T.S., SURYANARAYANAN T.S., SANYAL K. (2022): Hypersaline fungi as a source of potentially active metabolites against pathogenic Candida species. [antifungal, bioprospecting, filamentous fungi, extremotolerant, hypersaline environment.] Czech Mycology 74(1): 93-101 (published: 22nd April, 2022)
abstract
Opportunistic and nosocomial human infections by various Candida species are of serious global health concern especially due to the spread of drug resistant strains and lack of treatment options. One of the main problems of bioprospecting for novel antimycotics is the rediscovery of already known molecules. To reduce the chances of such rediscoveries, one option is to search for unique metabolites from microbes of less studied and extreme habitats. Thirty-five fungal strains were isolated from solar salterns and the methanolic extracts of their culture supernatants were tested for the inhibition of human-pathogenic Candida albicans, C. dubliniensis, C. glabrata, C. lusitaniae, C. tropicalis, and two clinical isolates of C. auris. Of the fungi screened, two, viz. Curvularia nodosa and Fusarium cf. foetens, showed significant growth inhibition of all the Candida species. Although the effective molecules were not identified in this preliminary screening, it highlights the importance of bioprospecting fungi from extreme environments which have been neglected in the search for novel antibiotics.
SAWMYA K., VASUDEVAN T.G., MURALI T.S. (2013): Fungal endophytes from two orchid species - pointer towards organ specificity. [fungal endophytes, environment, orchids, Bulbophyllum neilgherrense, Pholidota pallida] Czech Mycology 65(1): 89-101 (published: 10th June, 2013)
abstract
Fungal endophytes may influence plant communities by altering the host’s fitness either positively or negatively. Little is known, however, about their host/organ specificity, life style and role in plantfungus symbiosis under varying environmental conditions. We compared the leaf and root endophyte assemblages of two orchids (Bulbophyllum neilgherrense and Pholidota pallida) from natural forests and greenhouse conditions. Xylariaceae species were consistently associated with leaf and root tissues, while Guignardia and Pestalotiopsis were found predominantly in the leaf tissues of both orchids. Correspondence analysis of the endophyte assemblages showed that the endophytes exhibited distinct organ but little host specificity. More endophytes were shared by the two different orchids growing in the same location when compared to endophyte assemblages of a single orchid from different locations. Considering the influence of endophytes in shaping the host’s community, diverse habitats must be screened vigorously to address questions regarding the role of endophytes in hostendophyte interactions.
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