Interaction of the effects of death cap and ethanol in rats was studied. Ethanol was found to have no protective effect during poisoning by Amanita phalloides. In contrast, it burdened hepatocytes with its own detoxification and made the absorption of the fungal toxins easier due to a changed membrane fluidity. Besides, ethanol was responsible for an increased deimage to the cellular membranes by free radicals that originated in its metabolism. The potentiated effects of the two noxae is thus defined. Our results suggest that the intoxication by A. phalloides parallelled by digestion of a small dose of an alcoholic drink will have a more serious course and worse prognosis.
Klán J., Zima T., Baudišová D. (1994): Potentiated effect of ethanol on Amanita phalloides poisoning. – Czech Mycology 47(2): 145–150.
